A Budding Yeast Model for Human Disease Mutations in the EXOSC2 Cap Subunit of the RNA Exosome
Maria C. Sterrett, Liz Enyenihi, Sara W. Leung, Laurie Hess, Sarah E. Strassler, Daniela Farchi, Richard Sean Lee, Elise S. Withers, Isaac Kremsky, Richard E. Baker, Munira A. Basrai, Ambro van Hoof, Milo B. Fasken, Anita H. Corbett
The paper creates a yeast model of SHRF mutations in EXOSC2 and compares it to an EXOSC3 mutation model, showing distinct RNA exosome functional impacts.
RNA · Jun 23, 2021Peer-reviewedGenetics