Author

Lea Järke

Christian-Albrechts-Universität zu Kiel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Christoph KaletaiD· 2 shared Christoph RöckeniD· 2 shared Felix SommeriD· 2 shared Philip C RosenstieliD· 2 shared Saskia Weber‐Stiehl· 2 shared Andreas TholeyiD· 1 shared Burkhardt FlemeriD· 1 shared Fenja Amrei Schuran· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Christoph KaletaORCID

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2 papers

Recent·Most cited

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in mice

Lea Järke, Saskia Weber‐Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip C Rosenstiel, Felix Sommer

This study shows that deleting HKDC1 in intestinal epithelial cells reduces tumor growth and protects against colorectal cancer in mice by impairing mitochondrial function and cell proliferation.

癌症：英文版 · Mar 20, 2025Peer-reviewedCancer Biology

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

Saskia Weber‐Stiehl, Jan Taubenheim, Lea Järke, Christoph Röcken, Stefan Schreiber, Konrad Aden, Christoph Kaleta, Philip C Rosenstiel, Felix Sommer

The paper examines the relationship between HK2 expression and inflammation severity in IBD patients using bulk transcriptome data and confirms findings at the cellular and protein levels.

BMC Medicine · Oct 23, 2024Peer-reviewedImmunology