Jan Rupp

The paper identifies HERC4 as a regulator of ROS-induced DNA damage during bacterial and viral-bacterial infections, showing its role in DNA repair and potential as a therapeutic target.

This study identifies niche-specific metabolic differences in non-typeable Haemophilus influenzae (NTHi) isolates from ear, pharynx, and lung sites, revealing site-specific metabolic profiles.

The paper identifies negative hysteresis as a robust phenomenon in Pseudomonas aeruginosa that enhances antibiotic efficacy through increased aminoglycoside uptake after beta-lactam treatment.

This paper uses metatranscriptomics and metabolic modeling to analyze patient-specific urinary microbiomes during infection, identifying metabolic dependencies and potential interventions for antibiotic-resistant UTIs.

This study shows that deleting HKDC1 in intestinal epithelial cells reduces tumor growth and protects against colorectal cancer in mice by impairing mitochondrial function and cell proliferation.

This study shows combining cefiderocol with aztreonam delays resistance development in NDM-producing E. cloacae complex isolates, with a 4-fold MIC reduction being a key predictor.

This study characterizes neonatal Staphylococcus capitis NRCS-A isolates and compares them with non-NRCS-A isolates from neonates and adults, identifying genetic and phenotypic traits associated with their success in NICUs.

The paper analyzes global S. maltophilia strains to show genetic diversity and intra-hospital transmission.

This study shows that a mutation in mt-Nd2, a mitochondrial complex I gene, reduces lifespan and increases glucose intolerance in mice by affecting tryptophan levels and aging pathways.

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.