The tunicate metabolite 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine targets ion channels of vertebrate sensory neurons
Noemi D. Paguigan, Yannan Yan, Manju Karthikeyan, Kevin Chase, Jackson Carter, Lee S. Leavitt, Albebson L. Lim, Zhenjian Lin, Tosifa A. Memon, Sean B. Christensen, Bo Hjorth Bentzen, Nicole Schmitt, Christopher A. Reilly, Russell W. Teichert, Shrinivasan Raghuraman, , Eric W. Schmidt
This study identifies DIMTA, a marine tunicate metabolite, as a selective inhibitor of cold thermosensors in mice, increasing cold sensation threshold by >3°C.
ACS Chemical Biology · Aug 23, 2021Peer-reviewedNeuroscience