Kevin Chase

The paper identifies how neuropeptide genes in cone snails evolved into toxins through mechanisms like exon shuffling and transposable element-driven recombination, revealing dynamic genome-molecular innovation interactions.

The paper identifies molecularly similar fast trill neurons in clawed frogs with different vocal behaviors, suggesting evolutionary conservation and potential non-vocal functions.

This study characterizes conkazal-M1, a conotoxin from Conus magus, showing it acts as both a protease inhibitor and a neuroactive peptide.

The paper identifies prey-specific toxins in cephalopod venom, including neurotensin-mimicking peptides that target fish, revealing an evolutionary strategy for broad venom activity.

This study identifies DIMTA, a marine tunicate metabolite, as a selective inhibitor of cold thermosensors in mice, increasing cold sensation threshold by >3°C.

The paper identifies molleamine C as a partial antagonist of nicotinic acetylcholine receptors with potential for neuroactive drug development.