Lei Dai

A genome-resolved atlas reveals lineage-specific activity patterns of prophages in cultured human gut bacteria

The paper develops ACTIVE to profile prophage activity in gut bacteria, revealing 5.4% of prophages are active under standard culture and identifying distinct viral lineages.

Pyruvate-driven hydrogen production promotes polyphenol bioconversion by gut bacteria

The paper develops a medium to enhance gut bacteria's conversion of polyphenols into bioactive metabolites by promoting pyruvate metabolism and hydrogen production.

Neocortical temporal patterning by a two-layered regulatory network

The paper identifies a two-layered regulatory network governing temporal patterning in neocortical development through single-cell multi-omics analysis.

A CRISPR/SpCas9M-reporting system for efficient and rapid genome editing in Caulobacter crescentus

This paper develops a CRISPR/SpCas9M-reporting system for efficient genome editing in Caulobacter crescentus and related bacteria, achieving up to 80% editing efficiency with minimal off-target effects.

Degradation of indole-3-acetic acid by plant-associated microbes

This study identifies bacterial isolates capable of degrading indole-3-acetic acid (IAA) from Arabidopsis and rice roots, revealing their functional roles and association with IAA producers.

StrainPanDA: linked reconstruction of strain composition and gene content profiles via pangenome-based decomposition of metagenomic data

StrainPanDA links strain composition and gene content in metagenomic data to understand microbial functions and phenotypes.