Author

Leianna Brune

Feinstein Institute for Medical Research

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Immunology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Ailing LuiD· 1 shared Amanda HuangiD· 1 shared Betsy Jo BarnesiD· 1 shared Bharati MattaiD· 1 shared Matthew A. MossiD· 1 shared Zarina BruneiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperImmunology

Ailing LuORCID

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1 paper

Recent·Most cited

IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation

Zarina Brune, Ailing Lu, Matthew A. Moss, Leianna Brune, Amanda Huang, Bharati Matta, Betsy Jo Barnes

This study identifies IRF5 as a key regulator of T cell effector function through mTORC1 signaling, glutamine metabolism, and post-transcriptional control following TCR activation.

bioRxiv · Aug 26, 2024 · PreprintImmunology