Matthew A. Moss

IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation

This study identifies IRF5 as a key regulator of T cell effector function through mTORC1 signaling, glutamine metabolism, and post-transcriptional control following TCR activation.

Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis

The paper shows pregnancy-induced changes in mammary epithelial cells lead to NKT cell expansion and promote mammary oncogenesis through CD1d expression.

Pregnancy reprograms the enhancer landscape of mammary epithelial cells and alters the response to cMYC-driven oncogenesis

The paper investigates how pregnancy alters the enhancer landscape of mammary epithelial cells and affects their response to cMYC-driven oncogenesis, finding that post-pregnancy cells are resistant to cMYC-induced proliferation.