Charles Joly-Beauparlant

This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.

This study shows that SARS-CoV-2 Nsp2 drives immunopathology by reprogramming host immune responses, leading to more severe inflammation compared to its deletion mutant.

This study identifies Parkinson's disease risk genes expressed at brain barriers and shows poor transcript-protein correlation and low interspecies conservation.

This study investigates how NuA4/TIP60 complex acetylates and loads H2A.Z onto chromatin to regulate transcription, showing that acetylation precedes chromatin incorporation at promoters.

This study shows Sfp1 and NuA4 interact in a TORC1-dependent manner to regulate ribosome biogenesis gene transcription through distinct mechanisms.

The paper identifies and characterizes multiple protein complexes associated with MRG15 and MRGX, revealing their roles in chromatin modification and transcription regulation.

The paper introduces cis-regulatory hubs (CRHs) as a 3D model of gene regulation in neurons, showing their enrichment in schizophrenia-associated genes, SNPs, and heritability.

The paper shows GFI1 recruits the NuRD complex to open chromatin regions in myeloid progenitors, influencing chromatin structure and gene regulation during neutrophil differentiation.

The paper benchmarks DIA acquisition methods and software tools using a complex proteomic standard, identifying optimal workflows for LC-MS/MS proteomic analyses.

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.