Author

Leslie Hoerner

Friedrich Miescher Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Christiane Wirbelauer· 2 shared Dirk SchübeleriD· 2 shared Lukas BurgeriD· 2 shared Murat IskariD· 2 shared Sevi DurduiD· 2 shared Daniel HeßiD· 1 shared Fumiya Moribe· 1 shared Luke IsbeliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Christiane Wirbelauer

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2 papers

Recent·Most cited

Modular control of CpG islands by chromatin-opening transcription factors specifies transcription start sites

Fumiya Moribe, Murat Iskar, Sevi Durdu, Christiane Wirbelauer, Leslie Hoerner, Sebastien Smallwood, Lukas Burger, Dirk Schübeler

The paper shows chromatin-opening transcription factors determine transcription start sites by binding near the initiation site, with loss of these factors redirecting initiation to secondary sites.

bioRxiv · May 6, 2026 · PreprintMolecular Biology

Chromatin-dependent motif syntax defines differentiation trajectories

Sevi Durdu, Murat Iskar, Luke Isbel, Leslie Hoerner, Christiane Wirbelauer, Lukas Burger, Daniel Heß, Vytautas Iešmantavičius, Dirk Schübeler

The paper identifies chromatin-dependent motif syntax that distinguishes binding patterns of NGN2 and MyoD1 during differentiation, revealing how context-specific chromatin states influence transcription factor specificity.

Molecular Cell · Aug 1, 2025Peer-reviewedGenomics