Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease
Hannah McAlister, Heather J. Merchant, Verity F. T. Mitchener, Noemi Gatto, Millie J. Thackray, Emily Blackburn, Libby Shackleton, Matthew S. Gentry, I. Lorena Arancibia‐Cárcamo, Amy F. Lloyd
This study identifies glycogen metabolism as a key regulator of microglial function in Alzheimer's disease, showing that glycogenolysis drives microglial activation and that inhibiting it reduces Abeta uptake and functional impairment.
bioRxiv · Jul 16, 2026 · PreprintNeuroscience