Matthew S. Gentry

The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.

This study shows systemic hypoxia promotes lung adenocarcinoma progression by mobilizing glycogen via GAA, supporting tumor growth through metabolic remodeling.

This study identifies glycogen metabolism as a key regulator of microglial function in Alzheimer's disease, showing that glycogenolysis drives microglial activation and that inhibiting it reduces Abeta uptake and functional impairment.

This study shows PCSK9 inhibitors reduce AAA growth by enhancing macrophage efferocytosis through MerTK-dependent mechanisms and altering lipid metabolism in the aortic wall.

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

The paper maps spatial metabolome coherence across mouse brain regions using MALDI imaging and optimal transport, showing preserved coherence in Alzheimer's model despite metabolic changes and demonstrating intervention effects.

This study identifies alcohol dehydrogenases as critical for Streptococcus pneumoniae fitness during influenza-driven superinfection, revealing a metabolic dependency that can be targeted therapeutically.

This study shows that dopamine auto receptors regulate glycogen storage in midbrain dopaminergic neurons, linking neuromodulation to metabolic resilience and vulnerability in Parkinson's disease.

This study quantifies amylopectin granule dynamics in Toxoplasma gondii tissue cysts during chronic infection, revealing a temporal cycle linked to bradyzoite replication and mitochondrial activity.

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

MetaVision3D converts serial 2D MALDI mass spectrometry imaging sections into a 3D spatial metabolome atlas using computer vision techniques.

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.