Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate
Ziyang Ye, Alireza Khademi, Renée Louane Barbosa, Foster Birnbaum, Margaret R. Brown, Colin E Fowler, Arianna Arroyo-Ortega, Daniel Lee, Lijuan Feng, Leah A. Gates, Agata L. Patriotis, Amy E. Keating, Francisco J. Sánchez Rivera, Yadira M. Soto‐Feliciano
This study develops CHANCLA, a multiomic platform to screen oncohistones, revealing their impact on chromatin and cell fate through functional and structural analyses.
bioRxiv · Apr 17, 2026 · PreprintCancer Biology