Yadira M. Soto‐Feliciano

PRMT5 inhibition induces a histone methylation switch that drives chromatin plasticity, drug resistance, and metastatic progression

This study shows PRMT5 inhibition causes splicing defects and epigenetic changes leading to drug resistance and metastatic progression in lung adenocarcinoma.

Paternal regulation of H3K4 methylation supports tumor suppressor networks in mammals intergenerationally

The paper shows that paternal KDM6A loss disrupts H3K4 methylation at tumor suppressor gene promoters, increasing cancer risk in offspring.

Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System

Proteogenomic analysis of up to 11 CPTAC cohorts shows ubiquitin-proteasome proteins often diverge from transcripts; TP53-mutant tumors elevate UBR5 protein, while TRIM28 prognosis is lineage-dependent.

Epigenetic Reactivation of Lineage Differentiation to Target Leukemia

This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.

Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate

This study develops CHANCLA, a multiomic platform to screen oncohistones, revealing their impact on chromatin and cell fate through functional and structural analyses.

The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.