Author

Agata L. Patriotis

Howard Hughes Medical InstituteORCID 0000-0002-8237-975XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Yadira M. Soto‐FelicianoiD· 2 shared Alexey A. SoshneviD· 1 shared Alireza Khademi· 1 shared Amy E. KeatingiD· 1 shared Annaelle Djomo· 1 shared Arianna Arroyo-Ortega· 1 shared Benjamin A. Garcia· 1 shared C. David AllisiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Yadira M. Soto‐FelicianoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate

Ziyang Ye, Alireza Khademi, Renée Louane Barbosa, Foster Birnbaum, Margaret R. Brown, Colin E Fowler, Arianna Arroyo-Ortega, Daniel Lee, Lijuan Feng, Leah A. Gates, Agata L. Patriotis, Amy E. Keating, Francisco J. Sánchez Rivera, Yadira M. Soto‐Feliciano

This study develops CHANCLA, a multiomic platform to screen oncohistones, revealing their impact on chromatin and cell fate through functional and structural analyses.

bioRxiv · Apr 17, 2026 · PreprintCancer Biology

The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

Agata L. Patriotis, Yadira M. Soto‐Feliciano, Douglas Barrows, Laiba F Khan, Marylène Leboeuf, Peder J. Lund, Matthew R. Marunde, Annaelle Djomo, Michael‐Christopher Keogh, Thomas S. Carroll, Benjamin A. Garcia, Alexey A. Soshnev, C. David Allis

This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.

Genes & Development · Feb 9, 2026Peer-reviewedGenetics

Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia

Xiao Xu, Elitsa I Stoyanova, Agata L. Patriotis, Jie Xing, Deborah C. Mash, Nathaniel Heintz

The paper identifies molecular differences between rodent and human neuronal and glial cell types using gene expression and epigenetic data from postmortem human brains.

eLife · Oct 15, 2018Peer-reviewedNeuroscience