APOE4 and INPP5D converge on membrane mechanics to regulate endocytosis in human astrocytes
Artur S. Gevorgyan, Lila M Gordon, Christian A. Combs, Adrian Lita, Linda G. Yang, Carla Cuní‐López, Jessica T. Root, Mioara Larion, Justin W. Taraska, Priyanka S. Narayan
This study shows APOE4 impairs endocytosis in astrocytes by altering membrane mechanics, and INPP5D restores this process by promoting clathrin curvature and maturation.
bioRxiv · May 25, 2026 · PreprintCell Biology