Author

Linda G. Yang

National Institutes of HealthORCID 0000-0002-1671-8792Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

Jessica T. RootiD· 3 shared Priyanka S. NarayaniD· 3 shared Adrian LitaiD· 2 shared Carla Cuní‐LópeziD· 2 shared Christian A. CombsiD· 2 shared Mark CooksoniD· 2 shared Mioara LarioniD· 2 shared Alexandra G. BeilinaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

Jessica T. RootORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

APOE genotypes differentially remodel the astrocytic lipiddroplet-associated proteome to shape lipid droplet dynamics

Carla Cuní‐López, Jessica T. Root, Ying Hao, Niek Blomberg, Sascha Koppes-den Hertog, Dylan C. Sacks, Amber E. Trujillo, Rodolfo Ghirlando, Isabelle Kowal, Jacob Epstein, Linda G. Yang, Mark Cookson, Elise Marsan, Rik van der Kant, Martin A. Giera, , Priyanka S. Narayan

This study shows APOE genotypes alter astrocytic lipid droplet proteomes and dynamics, with APOE4 showing resistance to lipophagy, suggesting impaired clearance as a mechanism for AD risk.

Nature Communications · Aug 19, 2026Peer-reviewedCell Biology

APOE4 and INPP5D converge on membrane mechanics to regulate endocytosis in human astrocytes

Artur S. Gevorgyan, Lila M Gordon, Christian A. Combs, Adrian Lita, Linda G. Yang, Carla Cuní‐López, Jessica T. Root, Mioara Larion, Justin W. Taraska, Priyanka S. Narayan

This study shows APOE4 impairs endocytosis in astrocytes by altering membrane mechanics, and INPP5D restores this process by promoting clathrin curvature and maturation.

bioRxiv · May 25, 2026 · PreprintCell Biology

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

Roxan A. Stephenson, Jordy Sepulveda, Kory R. Johnson, Adrian Lita, Jaanam Gopalakrishnan, Dominic J. Acri, Alexandra G. Beilina, Linling Cheng, Linda G. Yang, Jessica T. Root, Michael Emmerson Ward, Christian A. Combs, William C. Skarnes, Mark Cookson, Han‐Yu Shih, , Priyanka S. Narayan

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

Cell Reports · Jul 1, 2025Peer-reviewedCell Biology

Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility.

Austin J Rivera, Jou-Hsuan Roxie Lee, Shruti Gupta, Linda G. Yang, Raghuveera Kumar Goel, Joseph Zaia, Nelson C. Lau

The paper identifies Traffic Jam as a transcription factor regulating the Flam piRNA cluster and Piwi pathway to suppress transposons and maintain Drosophila fertility.

Cell Reports · Apr 1, 2025Peer-reviewedGenetics