Uridine cytidine kinases dictate the therapeutic response of molnupiravir via its bioactivation
Huazhang Shu, Sushma Sharma, Seher Alam, Lilian Frank, Marianna Tampere, André B. P. Kuilenburg, Nicholas C.K. Valerie, Mikael Altun, Andrei Chabes, Sean G. Rudd, Si Min Zhang
This study identifies uridine cytidine kinases (UCKs) as key enzymes that phosphorylate molnupiravir's active metabolite, influencing its antiviral efficacy and selectivity against SARS-CoV-2.
bioRxiv · May 13, 2025 · PreprintMicrobiology