Sushma Sharma

The paper identifies suppressor variants that alter gene essentiality across yeast strains, revealing context-dependent genetic mechanisms.

The paper shows that yeast rapidly adapts to glucose depletion by using metabolic changes to control translation, prioritizing stress-response genes.

This study identifies uridine cytidine kinases (UCKs) as key enzymes that phosphorylate molnupiravir's active metabolite, influencing its antiviral efficacy and selectivity against SARS-CoV-2.

This study identifies Pin4 as a yeast RNA-binding protein that coordinates post-transcriptional and transcriptional responses to energy depletion by regulating mRNA binding and transcriptional shifts during glucose withdrawal.

This study shows that physiological levels of rNMPs in mtDNA do not compromise its stability across mouse lifespan.

The paper identifies Mck1 as a key S-phase checkpoint effector that regulates dNTP homeostasis by modulating RNR and HUG1 expression in response to replication threats.