Topoisomerase IIIα resolves inter- and intra-molecular intertwines during DNA replication
Sabrina X. Van Ravenstein, Lillian V. Campos, Gábor M. Harami, Darren R. Heintzman, Steven N Dahmen, William G. Dunphy, Keir Cajal Neuman, James M. Dewar
This study shows that TOP3 resolves both inter- and intra-molecular DNA intertwines during replication, promoting fork progression and daughter strand unlinking, especially when TOP2 is compromised.
bioRxiv · Jul 1, 2026 · PreprintBiochemistry