James M. Dewar

This study shows EXO1-mediated strand-independent degradation of uncoupled replication forks activates ATR and limits fork progression in Xenopus egg extracts.

This study shows that TOP3 resolves both inter- and intra-molecular DNA intertwines during replication, promoting fork progression and daughter strand unlinking, especially when TOP2 is compromised.

The paper investigates how abasic sites on leading and lagging strands affect replisome progression and bypass mechanisms in Xenopus egg extracts, showing distinct stalling effects but similar reliance on translesion synthesis.

The paper shows that replication fork collapse at SSBs leads to seDSBs resolved by homologous recombination, but DNA synthesis downstream is inefficient, while deDSBs allow efficient synthesis without recombination.

This study shows that single-strand breaks cause replisome disassembly by generating different fork collapse structures depending on the strand, with CMG being passively removed during leading strand collapse and actively unloaded during lagging strand collapse.