Gábor M. Harami

This study shows that TOP3 resolves both inter- and intra-molecular DNA intertwines during replication, promoting fork progression and daughter strand unlinking, especially when TOP2 is compromised.

This study develops SHAN-seq to map type II topoisomerase cleavage sites on DNA with high sensitivity, revealing hundreds of sites and enzyme-specific variations.

This study creates and characterizes a zebrafish model for Bloom syndrome, showing that blm mutants exhibit shortened lifespan, reduced fertility, and germ line developmental issues.