Spermidine alleviates depression via control of the stress response
Sarah Mackert, Christine Niemeyer, Yara Mecdad, Tim Ebert, Thomas Bajaj, Sylvère Durand, Sebastian J. Hofer, Andreas Zellner, Bianca Besteher, Jan Engelmann, Barbara Gisabella, Valerie Kempf, Lily A. Heckmann, Marcel Laakmann, Emily L. Newman, , Nils C. Gassen
This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.
bioRxiv · Dec 4, 2024 · PreprintNeuroscience