Jan Engelmann

This study shows that deleting glucocorticoid receptors in postnatal oligodendrocyte precursor cells reduces oligodendrocyte density, alters hippocampal activity, and impairs memory in adult mice.

This study identifies DNA methylation changes over time during antidepressant treatment in MDD, linking them to neuroplasticity and inflammation, and shows differences between responders and non-responders.

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

This study identifies HNK's mechanism of action by analyzing CSF proteome changes, showing its impact on glucocorticoid receptor signaling and potential upstream regulators.