Barbara Gisabella

Polysome Profiling Method for Low-Input Human Postmortem Brain

This paper develops a low-input polysome profiling protocol for human postmortem brain tissue and adapts it for neuronal cell lines and mouse brain.

Altered molecular signaling pathways in the hippocampus of rhesus monkeys following chronic alcohol use

This study identifies altered molecular pathways in the hippocampus of rhesus monkeys with chronic alcohol use, highlighting mitochondrial and synaptic changes and potential therapeutic targets.

Cross-Species Evidence for Hippocampal CACNA1C as a Therapeutic Target for Alcohol Use Disorder

The paper identifies CACNA1C as a therapeutic target for alcohol use disorder by showing increased expression in AUD and reduced ethanol-induced CPP with Nifedipine.

Sleep Deprivation Alters Hippocampal Dendritic Spines in a Contextual Fear Memory Engram

The paper investigates how sleep deprivation affects dendritic spine density in neurons encoding contextual fear memories, finding reduced spine density in sleep-deprived mice.

Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex

This study shows psilocybin reduces reward-seeking behavior and increases activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex in rats.

Spermidine alleviates depression via control of the stress response

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

Circadian Rhythms of Perineuronal Net Composition

The paper investigates circadian rhythms of perineuronal nets (PNNs) in rodents and humans, showing diurnal and circadian variations and disruption by sleep deprivation.