Phosphorylation-dependent tuning of mRNA deadenylation rates
James A. W. Stowell, Conny Wing-Heng Yu, Zhuo Angel Chen, Lily K. DeBell, Giselle C. Lee, Tomos E. Morgan, Ludwig Roman Sinn, Sylvie Agnello, Francis J. O’Reilly, Juri Rappsilber, Stefan M.V. Freund, Lori A. Passmore
The paper shows phosphorylation modulates deadenylation rates via multivalent interactions in RNA adaptors, enabling graded regulation of mRNA decay.
Nature Structural & Molecular Biology · Nov 3, 2025Peer-reviewedMolecular Biology