Author

James A. W. Stowell

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 5

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1 Assay:multiome· 1 Approach:statistical model· 1

Frequent Co-Authors

Lori A. PassmoreiD· 5 shared Francis J. O’ReillyiD· 3 shared Juri RappsilberiD· 3 shared Conny Wing-Heng YuiD· 2 shared Eva AbsmeieriD· 2 shared Ludwig Roman SinniD· 2 shared Stefan M.V. FreundiD· 2 shared Zhuo Angel CheniD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

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10 top collaborators · 33 mutual co-author links

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5 shared papersMolecular Biology

Lori A. PassmoreORCID

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5 papers

Recent·Most cited

Phosphorylation-dependent tuning of mRNA deadenylation rates

James A. W. Stowell, Conny Wing-Heng Yu, Zhuo Angel Chen, Lily K. DeBell, Giselle C. Lee, Tomos E. Morgan, Ludwig Roman Sinn, Sylvie Agnello, Francis J. O’Reilly, Juri Rappsilber, Stefan M.V. Freund, Lori A. Passmore

The paper shows phosphorylation modulates deadenylation rates via multivalent interactions in RNA adaptors, enabling graded regulation of mRNA decay.

Nature Structural & Molecular Biology · Nov 3, 2025Peer-reviewedMolecular Biology

RNA-binding proteins provide specificity to the PAN2-PAN3 mRNA deadenylation complex

Terence T. L. Tang, Francesco Zangari, Conny Wing-Heng Yu, James A. W. Stowell, Alžběta Roeselová, Stefan M.V. Freund, Anne‐Claude Gingras, Lori A. Passmore

This study shows that the PAN2-PAN3 deadenylation complex can be recruited to specific mRNAs via RNA adaptors, adding to the specificity of mRNA degradation.

bioRxiv · Sep 27, 2025 · PreprintMolecular Biology

Molecular insights into dynamic protein structures by high-contrast crosslinking mass spectrometry

Zhuo Angel Chen, Eva Absmeier, James A. W. Stowell, Ludwig Roman Sinn, Shabih Shakeel, Tamara Sijacki, Kendra Njo, Kolja Stahl, Edward Rullmann, Francis J. O’Reilly, Lori A. Passmore, Juri Rappsilber

This paper improves crosslinking mass spectrometry by using diazirine-based photo-crosslinking to better study dynamic protein regions and their conformational changes.

bioRxiv · Sep 2, 2024 · PreprintMolecular Biology

Specific recognition and ubiquitination of slow-moving ribosomes by human CCR4-NOT

Eva Absmeier, Viswanathan Chandrasekaran, Francis J. O’Reilly, James A. W. Stowell, Juri Rappsilber, Lori A. Passmore

This study identifies how human CCR4-NOT complex recognizes and ubiquitinates stalled ribosomes during mRNA decay in response to sub-optimal codons.

bioRxiv · Jul 24, 2022 · PreprintMolecular Biology

The mechanism of Ccr4-Not recruitment to specific mRNAs involves sequence-selective tethering by RNA-binding proteins

Michael W Webster, James A. W. Stowell, Lori A. Passmore

The paper shows that RNA-binding proteins selectively tether the Ccr4-Not complex to specific mRNAs through low-complexity sequences and RNA-binding domains, influencing mRNA stability.

bioRxiv · Nov 25, 2018 · PreprintMolecular Biology