Lin Cai

Oblique Thick Light-Sheet Microscopy with Spatiotemporal 3D Localization for RNA Imaging in Intact 50 μm-Thick Sections

This paper introduces a microscopy technique that enables 3D RNA imaging in thick brain sections by combining spatiotemporal localization with volumetric excitation, revealing detailed neuronal distributions and expression gradients.

Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system

This study shows neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican, identified through co-culture experiments and functional assays.

PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron

The paper introduces PointTree, a method for accurately reconstructing single-neuron axonal projections from brain imaging data, achieving significantly higher F1-scores than existing methods.