Shaoqun Zeng

Fast Loading and Transformation of Large-Volume Bioimaging Data Consistently Approaching the I/O Peak Speed

The paper introduces a bioimaging data processing pipeline that improves data transformation efficiency and accelerates downstream tasks by optimizing I/O throughput and reducing memory overhead.

PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron

The paper introduces PointTree, a method for accurately reconstructing single-neuron axonal projections from brain imaging data, achieving significantly higher F1-scores than existing methods.

Bi-channel Image Registration and Deep-learning Segmentation (BIRDS) for efficient, versatile 3D mapping of mouse brain

BIRDS is an open-source software for 3D mouse brain mapping that combines image registration and deep learning segmentation for efficient and versatile analysis.

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.

Highly efficient and super-bright neurocircuit tracing using vector mixing-based virus cocktail

This paper introduces MAP-ENVIVIDERS, a vector mixing-based virus cocktail that significantly improves neurocircuit tracing efficiency and sensitivity compared to existing methods.

A 3D High Resolution Generative Deep-learning Network for Fluorescence Microscopy Image

This paper introduces a 3D deep learning network using dual-GAN to recover high-resolution volume images from low-resolution ones in fluorescence microscopy.

RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations

The paper introduces a light-inducible recombinase system for targeted genomic modifications in neurons, enabling precise labeling and functional analysis of neural circuits in live mouse brains.

Narrowly confined and glomerulus-specific onset latencies of odor-evoked calcium transients in the periglomerular cells of the mouse main olfactory bulb

This study measures odor-evoked calcium transients in mouse periglomerular cells and finds that onset latencies are narrowly confined within glomerulus-specific groups.

Genetic Single Neuron Anatomy reveals fine granularity of cortical interneuron subtypes

The paper uses genetic labeling and high-resolution microscopy to reveal fine-grained subtypes of cortical interneurons in mice, showing distinct connectivity patterns.

Identifying weak signals in inhomogeneous neuronal images for large-scale tracing of neurites

This paper introduces ST-LFV, a method that improves weak signal identification in neuronal images, achieving higher recall and precision than existing tools for large-scale neurite tracing.