Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells
Lujia Chen, Ling Liang Dong, Jung Hoon Shin, Farid Shahid, Taylor Joseph Malone, Yan Ma, Sreerag Othayoth Vasu, Nai-Wen Tien, Kyle Cekada, Kevin Jiang Zhang, Lucy G. Anderson, Sarthak Chandra, Ila Fiete, Veronica A. Alvarez, Yi Gu
The paper shows that slow hippocampus-to-entorhinal plasticity underlies gradual grid cell map formation and fragmentation in novel environments through longitudinal imaging and modeling.
bioRxiv · Jul 30, 2025 · PreprintNeuroscience