Activation of the medial entorhinal cortex drives memory-guided navigation behavior
Yan Ma, Taylor Joseph Malone, Nai-Wen Tien, June Hoan Kim, Maxym Myroshnychenko, Jean Tyan, Daniel Yusufi, Farid Shahid, David A. Kupferschmidt, Yi Gu
This study shows that spatially consistent activation of the medial entorhinal cortex (MEC) biases reward-predictive behaviors and supports memory-guided navigation.
bioRxiv · Aug 6, 2026 · PreprintNeuroscience