Taylor Joseph Malone

Activation of the medial entorhinal cortex drives memory-guided navigation behavior

This study shows that spatially consistent activation of the medial entorhinal cortex (MEC) biases reward-predictive behaviors and supports memory-guided navigation.

The entorhinal spatial map integrates visual identity information of landmarks

This study shows that the medial entorhinal cortex encodes landmark identity through cue cells during navigation, distinct from spatial encoding by grid cells.

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairment

This study links tau pathology in the medial entorhinal cortex to spatial memory impairment by showing dysregulated neural activity and sex-specific resilience in PS19 tauopathy mice.

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

The paper shows that slow hippocampus-to-entorhinal plasticity underlies gradual grid cell map formation and fragmentation in novel environments through longitudinal imaging and modeling.

Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators

The paper shows that Slack channel activation moves FMRP/CYFIP1 from eIF4E to the channel, releasing eIF4E and stimulating translation of β-actin mRNA and cortical β-actin.

A consistent map in the medial entorhinal cortex supports spatial memory

The paper shows that a consistent spatial map in the medial entorhinal cortex is necessary for successful spatial memory in mice.