Brenna McMannon

Age-related changes in behavioural and neural variability in a decision-making task

This study examines age-related changes in neural and behavioural variability during a decision-making task in mice, finding increased neural variability and reduced variability quenching in specific brain regions.

Stress resilience is associated with transcriptional remodeling in the VTA

The paper identifies cell type-specific transcriptional changes in the VTA of resilient versus susceptible mice subjected to chronic stress, highlighting intercellular signaling and neural communication as key factors in resilience.

VTA dopamine neuron activity produces spatially organized stimulus and action value representations through conditioned reinforcement

This study investigates how VTA dopamine neuron activity shapes stimulus and action value representations in the striatum through conditioned reinforcement in mice.

A Brain-Wide Map of Neural Activity during Complex Behaviour

The paper presents a brain-wide neural activity map from 621,733 neurons across 139 mice performing a decision-making task, showing how neural activity encodes task variables across brain regions.

A neural mechanism for learning from delayed postingestive feedback

The paper shows that postingestive malaise signals reactivate amygdala flavor representations, strengthening memory and resolving temporal credit assignment in aversive learning.

Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories

The paper shows that pre-existing visual responses in dopamine terminals predict individual learning trajectories in mice during a visual task.

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Overlapping representations of food and social stimuli in VTA dopamine neurons

The paper shows that VTA dopamine neurons respond to both food and social stimuli, with overlapping populations and increased overlap under hunger or social experience.

Data architecture for a large-scale neuroscience collaboration

The paper describes a modular data architecture for a neuroscience collaboration, enabling data contribution, access, and analysis across multiple labs.

A neural substrate of sex-dependent modulation of motivation by value

The paper identifies a neural substrate in mice where female-specific modulation of motivation by value is mediated by ACC-DMS neurons.