Farid Shahid

Circuit regulation along an activity continuum shapes flexible and stable representations during learning

The paper identifies mechanisms in the medial entorhinal cortex that balance representational flexibility and stability during learning through excitatory and inhibitory neuronal activity dynamics.

Activation of the medial entorhinal cortex drives memory-guided navigation behavior

This study shows that spatially consistent activation of the medial entorhinal cortex (MEC) biases reward-predictive behaviors and supports memory-guided navigation.

The entorhinal spatial map integrates visual identity information of landmarks

This study shows that the medial entorhinal cortex encodes landmark identity through cue cells during navigation, distinct from spatial encoding by grid cells.

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

The paper shows that slow hippocampus-to-entorhinal plasticity underlies gradual grid cell map formation and fragmentation in novel environments through longitudinal imaging and modeling.

Therapeutic Potential of PRMT1 as a Critical Survival Dependency Target in Multiple Myeloma

This study identifies PRMT1 as a critical survival dependency in multiple myeloma cells, showing that its inhibition reduces cell survival and impairs tumor growth.