Leveraging the dominant-negative effect of the kuru-protective G127Vprion protein variant as a novel therapeutic strategy
Jean R.P. Gatdula, Nadia A. Mirza-Romero, Isabel C. Orbe, Linnea M. Saunders, Samantha G Tolton, Janelle S. Vultaggio, Robert C.C. Mercer, Jason C. Bartz, Glenn C. Telling, Hasier Eraña, Joaquı́n Castilla, David A. Harris
This paper demonstrates that the G127V prion protein variant can prevent and suppress prion infection through a dominant-negative effect, suggesting its potential as a therapeutic strategy.
Neurobiology of Disease · Jun 29, 2026Peer-reviewedCell Biology