Cell BiologyNeurobiology of DiseasePeer-reviewed
Leveraging the dominant-negative effect of the kuru-protective G127Vprion protein variant as a novel therapeutic strategy
Jean R.P. Gatdula, Nadia A. Mirza-Romero, Isabel C. Orbe…·David A. Harris
This paper demonstrates that the G127V prion protein variant can prevent and suppress prion infection through a dominant-negative effect, suggesting its potential as a therapeutic strategy.