Mapping the latent CRBN-molecular glue degrader interactome
Pius Galli, Shuhao Xiao, Yanxiang Meng, Alexander Hanzl, Alexandra M. Bendel, Regina Baur, Jacob D. Aguirre, Anna M. Díaz-Rovira, Maximilian R. Stammnitz, Georg Kempf, Lukas Kater, Kenji Shimada, Ye Wei, Andreas Scheck, Dominique Klein, , Nicolas H. Thomä
The paper identifies CRBN-pomalidomide binders using a combination of GluePCA and AI-derived protein surface queries, revealing known and novel interactors for MGD development.
Nature Biotechnology · Aug 13, 2026Peer-reviewedMolecular Biology