Lack of dominant-negative activity for tumor-associated ZNRF3 missense mutations at endogenous expression levels
Shanshan Li, Jiahui Niu, Ruyi Zhang, Sanne Massaar, Madalena Neves Cabrita, Jenna van Merode, Nicky de Schipper, Lisa van de Kamp, Maikel Petrus Peppelenbosch, Ron Smits
This study shows that tumor-associated ZNRF3 missense mutations do not exhibit dominant-negative activity and instead act as loss-of-function mutations at endogenous levels.
Oncogene · Dec 14, 2024Peer-reviewedCancer Biology