Author

Ruyi Zhang

Erasmus MCORCID 0009-0004-0752-7179Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Jenna van Merode· 2 shared Jiahui NiuiD· 2 shared Maikel Petrus PeppelenboschiD· 2 shared Ron SmitsiD· 2 shared Shanshan Li· 2 shared Lisa van de Kamp· 1 shared Madalena Neves Cabrita· 1 shared Nicky de Schipper· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

Jenna van Merode

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Reassessment of RNF43 Function Reveals No Impact on Endogenous EGFR or BRAF Protein Stability

Jiahui Niu, Shanshan Li, Ruyi Zhang, Jenna van Merode, Maikel Petrus Peppelenbosch, Ron Smits

This study investigates whether RNF43 regulates EGFR or BRAF protein stability and finds no consistent evidence of such regulation, contradicting recent reports.

bioRxiv · Mar 20, 2026 · PreprintCell Biology

Lack of dominant-negative activity for tumor-associated ZNRF3 missense mutations at endogenous expression levels

Shanshan Li, Jiahui Niu, Ruyi Zhang, Sanne Massaar, Madalena Neves Cabrita, Jenna van Merode, Nicky de Schipper, Lisa van de Kamp, Maikel Petrus Peppelenbosch, Ron Smits

This study shows that tumor-associated ZNRF3 missense mutations do not exhibit dominant-negative activity and instead act as loss-of-function mutations at endogenous levels.

Oncogene · Dec 14, 2024Peer-reviewedCancer Biology