Michael Holtmannspötter

This study reports cryo-EM structures of human ABCA2, revealing its cholesterol transport mechanism and novel conformational changes.

This study identifies VPS13C/PARK23 as a key protein involved in lysosomal repair by facilitating lipid transfer and membrane remodeling in response to damage.

This study shows human-restricted Salmonella retain preassembled flagella during host cell invasion, using them for intracellular motility and vacuolar escape, while non-typhoidal Salmonella do not.

The paper introduces an improved HaloTag variant, HT-SP5, that enables more sensitive and earlier detection of T3SS-translocated effector proteins in living cells.

This paper introduces a nanopatterning toolbox to study multiprotein assemblies in live cells, demonstrating its application to the myddosome complex and revealing nanoscale organization.

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

This study shows hydrogen peroxide modulates axonal microtubule dynamics and induces distinct phosphorylation patterns in microtubule proteins through specific signaling pathways.

This paper shows that N-terminal tagging of Exo70 disrupts its assembly with the exocyst complex and alters its spatiotemporal behavior at the plasma membrane.

The paper compares Janelia Fluor dyes and TMR for fluorescence preservation in EM-compatible in-resin CLEM, identifying JFX549 and JFX554 as optimal for signal intensity and background ratio.

This study shows that tau and α-synuclein regulate microtubule organization and transport in neuronal dendrites, with tau deficiency increasing dendritic complexity and transport efficiency.