Construction of a genome-wide pooled CRISPRi library as a resource for exploring the acid tolerance mechanism in Streptococcus mutans
Yaqi Chi, Chen Yuxing, Chongyang Yuan, Liuchang Yang, Mingrui Zhang, Xiaolin Chen, Yiran Zhao, Ming Li, Xiaoyan Wang, Yongliang Li
The paper constructs a genome-wide CRISPRi library to identify acid tolerance genes in S. mutans and finds 95 associated genes involved in metabolism, tRNA modification, and transcriptional regulation.
bioRxiv · Jul 22, 2025 · PreprintMicrobiology