Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
Denise Ragusa, Chun-Wai Wade Suen, Gabriel Torregrosa-Cortés, Fabio Pastorino, Ayona Johns, Ylenia Cicirò, Liza Dijkhuis, Susanne van den Brink, Michele Cilli, Connor Byrne, Giulia-Andreea Ionescu, Joana Cerveira, Kamil R. Kranc, Víctor Hernández-Hernández, Mirco Ponzoni, , Cristina Pina
This paper introduces a 3D hemogenic gastruloid model to study infant acute myeloid leukemia origins, showing MNX1-driven transformation of erythroid-myeloid progenitors.
eLife · Sep 11, 2025Peer-reviewedDevelopmental Biology