Author

Denise Ragusa

Brunel University of LondonORCID 0000-0002-0303-8683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ayona Johns· 2 shared Chun-Wai Wade SueniD· 2 shared Cristina PinaiD· 2 shared Gabriel Torregrosa-CortésiD· 2 shared Ylenia CiciròiD· 2 shared Alfonso Martínez AriasiD· 1 shared Alice GiustacchiniiD· 1 shared Anna BigasiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Ayona Johns

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3 papers

Recent·Most cited

Cell BiologyDevelopmental CellPeer-reviewedMar 17, 2026

Multi-omic analyses reveal a differential contribution of chromatin-associated PP1 holoenzymes to mitotic exit and G1 re-establishment.

Konstantinos Stamatiou, Florentin Huguet, Marta Izabela Budzinska…·Paola Vagnarelli

The paper investigates the role of three chromatin-associated PP1 targeting subunits in mitotic exit and G1 re-establishment using multi-omic analyses.

2 citations

humanChIP-seq

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Developmental BiologyeLifePeer-reviewedSep 11, 2025

Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

Denise Ragusa, Chun-Wai Wade Suen, Gabriel Torregrosa-Cortés…·Cristina Pina

This paper introduces a 3D hemogenic gastruloid model to study infant acute myeloid leukemia origins, showing MNX1-driven transformation of erythroid-myeloid progenitors.

9 citations

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintSep 6, 2025

Integrated in silico and in vitro approaches identify a HSP90 drug vulnerability axis in t(7;12) infant leukemia stem-like cells

Ylenia Cicirò, Denise Ragusa, Emily M. Johnson…·Cristina Pina

The paper identifies HSP90 inhibitors as potential therapies for t(7;12)-AML by combining computational drug screening with in vitro experiments.

DOI 10.1101/2025.09.06.674620

humanbulk RNA-seq

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