Mu opioid receptors gate the locus coeruleus pain generator
Makenzie R. Norris, Chao‐Cheng Kuo, Samantha S. Dunn, Jenny R. Kim, Léa J. Becker, Gustavo Borges, Loc V. Thang, Kyle E. Parker, Jordan G. McCall
This study identifies mu opioid receptors in the locus coeruleus as critical regulators of pain, showing they gate the LC's role as a pain generator through bidirectional modulation of hyperalgesia.
bioRxiv · Oct 20, 2023 · PreprintNeuroscience