Léa J. Becker

This study shows spared nerve injury causes long-term, brain region- and sex-specific changes in oligodendrocyte density in mice, with no effect on oligodendrocyte precursor cells.

This study shows that maternal separation stress disrupts noradrenergic signaling in the locus coeruleus, leading to altered coping behaviors in adulthood.

This study shows that spared nerve injury in mice does not significantly affect negative affective behaviors in short-term tests but reveals reduced motivation for food rewards in long-term testing.

This study identifies mu opioid receptors in the locus coeruleus as critical regulators of pain, showing they gate the LC's role as a pain generator through bidirectional modulation of hyperalgesia.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

This study identifies the BLA-ACC pathway as critical for chronic pain-induced depression and reveals Sema4a's role in mood regulation through myelination impairments.