Dbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins
Priyanka Bansal, Shibojyoti Lahiri, Chandni Natalia Kumar, Jessica Furtmeier, Lorenz Spechtenhauser, Lorenzo Galanti, Juan de Dios Barba Tena, Erika Chacin, Garp Linder, María Ángeles Ortiz-Bazán, Marisa Müller, Petra Vizjak, Tobias Straub, Felix Mueller‐Planitz, Johannes Stigler, , Christoph F. Kurat
The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.
Nature Communications · Mar 28, 2026Peer-reviewedBiochemistry