Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia
Louise Cleal, Sophie L. McHaffie, Martin W. Lee, Nick D. Hastie, Ofelia M. Martínez-Estrada, You-Ying Chau
This study uses mouse models to show that Wt1 deletion in non-muscle mesenchyme of pleuroperitoneal folds causes congenital diaphragmatic hernia by disrupting tissue fusion and cell migration.
Disease Models & Mechanisms · Jan 1, 2021Peer-reviewedDevelopmental Biology