Dynamic Culture Improves the Predictive Power of Bronchial and Alveolar Airway Models of SARS-CoV-2 Infection
Claire H Caygill, Rose C. Lopeman, Kirstie A Lewis, Emily Richardson, Aitor Casas-Sánchez, Nick Heavey, Adam Winrow, Louise Howard, Chris Williams, Dominic Wooding, Thomas Edwards, Eric R. Lucas, Tomasz M. Kostrzewski, Andrew Owen, Shaun H. Pennington, Giancarlo A. Biagini
This study compares static and dynamic flow culture conditions in human airway models to show that dynamic flow improves tissue architecture, infection dynamics, and predictive power for SARS-CoV-2 infection.
bioRxiv · Jul 21, 2025 · PreprintMicrobiology