Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons
Lewis Macdonald, Gillian C.A. Taylor, Jennifer Margaret Brisbane, Ersi Christodoulou, Lucy Scott, Alex von Kriegsheim, Janet Rossant, Bin Gu, Andrew J. Wood
This paper develops CRISPR-engineered mouse lines for rapid and specific degradation of endogenous proteins in vivo, revealing stage-specific requirements for condensin complexes in lymphocyte division.
eLife · Jun 23, 2022Peer-reviewedGenetics