Bin Gu

The paper shows that tag fusions can have tissue-specific effects on protein stability in transgenic mice, depending on the cell and tissue environment.

This study shows SOX2 is not required for NUT carcinoma initiation or maintenance in mice, challenging its assumed oncogenic role and suggesting limited utility for SOX2-targeted therapies.

The paper shows that fibronectin-dependent tissue stiffness controls durotaxis and cell rearrangements through a phase transition model in mouse limb bud mesoderm.

This study shows YAP1 and WWTR1 are essential for decidualization and pregnancy in mice, with pdKO mice showing subfertility and altered gene expression.

This paper develops CRISPR-engineered mouse lines for rapid and specific degradation of endogenous proteins in vivo, revealing stage-specific requirements for condensin complexes in lymphocyte division.

This paper develops a Nutm1 knock-in reporter mouse model to visualize post-meiotic spermatids and monitor spermiogenesis in live mice.

This study develops a YAP fusion reporter mouse line and uses live imaging to analyze YAP localization dynamics during mouse embryonic development.

The paper presents two methods for generating endogenous protein reporters in mouse embryos: a split fluorescent protein approach and a V5 epitope tagging approach, each with distinct advantages for in vivo protein localization.

The paper introduces 2C-HR-CRISPR, a method for efficiently generating targeted large insertions in mouse embryos, and demonstrates its use in creating fluorescent reporter mouse lines and assessing protein function.